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新抗癌技术在小鼠测试中表现出根除晚期癌症的能力_我的网站

A |     Healthier Cookies Made from Banana Waste,Researchers from the Aligarh Muslim University in India and the University of Houston in the US discovered a new use for banana peels that normally go to waste, suggesting they may be turned into flour and then added to your favorite cookie recipe.,As it turns out, adding banana peel flour improves the nutritional value of cookies and imbues them with antioxidant properties useful for your health. There is slight downside though – the cookies became tougher the more banana flour you add, but miraculously soften after a certain period in storage. So, healthy cookies, anyone?,New Internet Highs (and Emergency Services),Rejoice the pilgrims to Kilimanjaro (Africa's highest mountain, in case you didn’t know), for the authorities of Tanzania announced the launch of a new project that will enable high-speed internet access on your mobile devices as you climb to the peak. Although the summit itself will be connected later on, the plan is to finish the project in October this year.,This is good news not only for those who love to post to their social media on the go, but also for those who love getting themselves in trouble! Previously, there was no cell service on the mountain and calling 911 in an emergency was kind of problematic. But not anymore!,Looking With a Fresh Pair of Eyes,Damage or degradation of corneas is no small issue – according to the scientists' estimates, some 12.7 million people around the world suffer vision loss due to it. And while cornea tissue is transplantable, there is not nearly enough donated tissue to serve all who faced this problem.,However, scientists from India and Iran managed to restore sight in 20 test patients during a trial of new bio-engineered (meaning you can always produce more) corneal tissue. It is made from the collagen of pig skin - not the rarest material in the world. Naturally, it will take time to scale the technology and thoroughly test it, but it's a success nonetheless.,Nanoparticles That Can Treat Cancer,Scientists of the Immanuel Kant Baltic Federal University in Russia have developed new nanoparticles made of gold and iron oxides that can destroy the cells of a tumor from the inside, while sparing the healthy ones, sources in the Russian Science Ministry told Sputnik. These particles, developed jointly with foreign scientists, can heat up and thus destroy cancerous cells.,The new technology tested well against cancer cells in breasts and walls of blood vessels. It also showed excelled biocompatibility – meaning it is not toxic for a human organism.。    我们对抗癌症--乃至所有疾病--的最大武器是我们的免疫系统，但即使它有时也需要一个帮手。免疫疗法提供了这种帮助，其中一种方法即所谓的免疫检查点抑制剂。这些药物能有效地解除免疫反应的自然刹车，从而使其能更长时间地跟癌症作斗争。尽管到目前为止这些药物看起来很有希望，但它们对一开始就没有什么免疫活动的“冷 ”肿瘤不起作用。因此，另一种类型的药物被称为STING激动剂，旨在将这些冷肿瘤激发为热肿瘤，从而使其更容易接受免疫疗法。

B | 但这些药物也有其缺点--即很难将它们瞄准癌细胞。而这正是这项新研究的意义所在。来自耶鲁大学和URI的研究人员使用了一种叫做低pH插入肽(pHLIP)的分子来引导药物到它需要去的地方。pHLIP被吸引到酸性环境中，就像癌症在自身周围形成的那种环境一样，非常方便。该研究的论文共同作者Donald Engelman说道：“当pHLIP遇到具有中性pH值的细胞膜时，它将短暂地坐在表面，然后拉走。

C | 但如果它处于酸性环境中，那么该肽就会折叠成一个螺旋，穿过细胞膜并停留在那里。”该团队将pHLIP跟STING激动剂结合起来，从而使前者将后者带到癌细胞并帮助它们在内部开始工作。

D | 在小鼠身上的测试证明是有希望的--研究人员给20只患有小结肠肿瘤的小鼠注射了pHLIP-STING，发现在一次注射后，18只小鼠的肿瘤在几天内完全消失了。在另一组有较大肿瘤的小鼠中，10只小鼠中有7只看到它们的肿瘤完全消失。相比之下，另一组10只小鼠只接受了STING，它们没有pHLIP的指导。所有10只小鼠的肿瘤生长都略有减缓，但肿瘤仍然存在。这种治疗甚至似乎具有持久的效果。

E | 研究小组将新的癌细胞注射到已无肿瘤的小鼠体内，结果60天后没有新的肿瘤出现，这表明免疫记忆已经形成。虽然这项技术听起来很有希望，但通常的注意事项也是适用的--动物试验的结果并不总是能延续到人类身上。

F | 在任何基于pHLIP-STING的潜在治疗方法能够找到用途之前还需要做更多的工作。

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Published on:10:50:06